Free BookBiotransformation and Metabolite Elucidation of Xenobiotics Characterization and Identification

[Ebook.LF8E] Biotransformation and Metabolite Elucidation of Xenobiotics Characterization and Identification

[Ebook.LF8E] Biotransformation and Metabolite Elucidation of Xenobiotics Characterization and Identification

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The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. Also, strategies for dealing with reactive intermediates in drug discovery and development are presented as well as case studies on improving the decision-making process in the structural modification of drug candidates. The last chapter discusses the regulatory perspectives of safety testing of drug metabolites and why, how, and when to test their safety. Drug Metabolism and Variability among Patients in Drug ... Drug Interactions Involving Induction of CYP3A. Treatment with drugs such as the rifamycins and some anticonvulsants predictably results in a marked reduction (up to ... Principles and Methods for Evaluating The Toxicity of ... international programme on chemical safety environmental health criteria 6 principles and methods for evaluating the toxicity of chemicals part i this report ... Society of Toxicology - Annual Meeting 2017 Cross-Industry and Regulatory Approach for the Identification and/or Qualification of Novel Safety Biomarkers of Drug-Induced Vascular Injury (DIVI) POLYCHLORINATED DIBENZODIOXINS POLYCHLORINATED ... who food additives series: 48. safety evaluation of certain food additives and contaminants polychlorinated dibenzodioxins polychlorinated dibenzofurans and Targeting multidrug resistance in cancer : Article ... Generation of mice deficient in the mdr1a (abcb1a) and mdr1b (abcb1b) genes or both has provided a valuable tool for the assessment of the contribution of Pgp to ... Drug safety glossaries & taxonomy You are here Biopharmaceutical Glossary Homepage/Search Drug Discovery & development Drug safety pharmacovigilance & post marketing surveillance
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